Professor Urology, Oncology
Director, Division of Urologic Oncology
James Buchanan Brady Urological Institute
Johns Hopkins Medical Institutions
Clinical Interests : Surgical Oncology, Bladder Cancer
Dr. Schoenberg’s main academic focus and area of clinical activity is the treatment of patients with bladder cancer. Dr. Schoenberg is involved in both basic and clinical research on the detection and management of patients with all forms of bladder cancer. His particular areas of clinical interest are the surgical treatment of invasive tumors and lower urinary tract reconstruction in both male and female patients.
1996 American Board of Urology Part II, Passed, February
1992 American Board of Urology Part I, Passed, June
1986 FLEX Examination, Pittsburgh, Pennsylvania, Passed, December
1994-present American Association of Cancer Research
1994-present American Urological Association
1995-present Mid-Atlantic Section/A.U.A.
1996-present Bladder Health Council/A.F.U.D.
1996-present Maryland Urological Society/Medical and Chirurgical Faculty of Maryland
1997-present Fellow, American College of Surgeons
1999-present Society of Urologic Oncology
2000-present Nominating Committee, Mid-Atlantic Section/A.U.A.
1980 Bachelor of Arts, cum laude, Yale University
1986 Alpha Omega Alpha, University of Texas
1998 Pfizer Scholar
1980 B.A., Yale University, New Haven, Connecticut
1986 M.D., University of Texas School of Medicine, Houston, Texas
Post Doctoral Training
1986-88 Post-graduate, General Surgery Training, University of Pennsylvania
1988-92 Resident, Department of Urology, University of Pennsylvania
1988-92 Assistant Instructor, Urology, Hospital of the University of Pennsylvania
1991-92 Chief Resident, Department of Urology, University of Pennsylvania
1992-94 Fellow, Brady Urological Institute, The Johns Hopkins Hospital
Research Activities and Publiciations
Schoenberg HW, Schoenberg MP, Gregory JG: Anterior bladder tube for continence in neurogenic bladder. Urology 5(6):759-761, 1975.
Benz C, Schoenberg MP, Choti M, Cadman E: Schedule-dependent cytotoxicity of methotrexate and 5-fluorouracil in human colon and breast tumor cell lines. Journal of Clinical Investigation 66:1162-1165, 1980.
Guardini MA, Schoenberg MP, Naso RA, Martin BA, Gutterman JU, Guevara J: Induction of proteins in human lymphoblastoid cells by recombinant alpha interferon. Journal of Interferon Research 4(1):67-69, 1984.
Schoenberg MP, Kelly A, Siegel A, Hanno PM, Wein AJ: The Kelly scrotal bridge. Urology 31:521, 1988.
Carpiniello VL, Schoenberg MP, Malloy TR: Long term follow-up of subclinical human papillomavirus infection treated with carbon dioxide laser and intraurethal 5-fluorouracil: treatment protocol. J Urol 143:726-728, 1989.
Schoenberg MP and Pollack HM: The Imaging Corner: Multilocular cystic nephroma. Contemporary Urology, November, 1990.
Schoenberg MP, Van Arsdalen KN, Wein AJ: The management of transitional cell carcinoma in solitary renal units. J Urol 146:700-703, 1991.
Carpiniello VL and Schoenberg MP: Laser treatment of condyloma and other external genital lesions. Seminars in Urology 9(3):175-179, 1991.
Shibutani YF, Schoenberg MP, Carpiniello VL, Malloy TR: Human papillomavirus infection associated with bladder cancer. Urology 40(1):15-17, 1992.
Schoenberg MP and Pollack HM: The Imaging Corner: Congenital mesoblastic nephroma. Contemporary Urology, December, 1992.
Schoenberg MP, Hakimi JM, Wang S, Bova GS, Epstein JI, Fischbeck KH, Isaacs WB, Walsh PC, Barrack ER: Microsatellite mutation (CAG 24-18) in the androgen receptor gene in human prostate cancer. Biochem. Biophys. Res. Comm. 198(1):74-80, 1994.
Schoenberg MP and Marshall FF: The use of colon segments: orthotopic ileocolic neobladder, Atlas Urologic Clinics of North America 3(2):55-63, 1995.
Chang WYH, Cairns P, Schoenberg MP, Polascik TJ, Sidransky D: Novel suppressor loci on chromosome 14q in primary bladder cancer. Cancer Res. 55:3246-3249, 1995.
Schoenberg MP, Cairns P, Brooks JD, Marshall FF, Epstein JI, Isaacs WB, Sidransky D: Frequent loss of chromosomes 8p and 13q in collecting duct carcinoma (CDC) of the kidney. Genes, Chromosomes & Cancer 12:76-80, 1995.
Perlman EJ, Brooks J, Gordon AH, Griffin CA, Schoenberg MP: Embryonal adenoma of the kidney in an adult: case report. J Urol 154:1473-1474, 1995.
Rosin MP, Cairns P, Epstein JI, Schoenberg MP, Sidransky D: An allelotype of carcinoma in situ of the human bladder. Cancer Res. 55:5213, 1995.
Polascik TJ, Cairns P, Chang WYH, Schoenberg MP, Sidransky D: Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma. Cancer Res. 55:5396-5399, 1995.
Mao L, Schoenberg MP, Scicchitano M, Erozan YS, Merlo A, Schwab D and Sidransky D: Molecular detection of primary bladder cancer by microsatellite analysis. Science 271:659-662, 1996.
Schoenberg MP, Walsh PC, Breazeale DR, Marshall FF, Mostwin JL, Brendler CB: Local recurrence and survival following nerve sparing radical cystoprostatectomy for bladder cancer: 10-year followup. J Urol 155:490-494, 1996.
Schoenberg MP, Kiemeney L, Walsh PC, Griffin CA, Sidransky D: Germline translocation t(5;20)(p15;q11) and familial transitional cell carcinoma. J Urol 155:1035-1036, 1996.
Schoenberg MP, Carter HB, Epstein JI: Ureteral frozen-section analysis during cystectomy: a reassessment. J Urol 155:1218-1220, 1996.
Polascik TJ, Cairns P, Epstein J, Fuzesi L, Sidransky D, Schoenberg MP: Distal nephron renal tumors: microsatellite allelotype. Cancer Res. 56:1892-1895, 1996.
Kiemeney LALM and Schoenberg MP: Familial transitional cell carcinoma: a review. J Urol 156:867-872, 1996.
Steiner G, Cairns P, Polascik T, Epstein J, Sidransky D and Schoenberg MP: High-density mapping of chromosomal arm 1q in renal collecting duct carcinoma: region of minimal deletion at 1q32.1-32.2. Cancer Res. 56:5044-5046, 1996.
Hakimi JM, Rondinelli RH, Schoenberg MP, Barrack ER: Androgen-receptor gene structure and function in prostate cancer. World J Urol 14:329-337, 1996.
Kiemeney LA, Moret NC, Witjes JA, Schoenberg MP and Tulinius H: Familial transitional cell carcinoma among the population of Iceland. J Urol 157:1649-1651, 1997.
Hakimi JM, Schoenberg MP, Rondinelli RH, Piantadosi S and Barrack ER: Androgen receptor variants with short glutamine or glycine repeats may identify unique subpopulations of men with prostate cancer. Clinical Cancer Research 3:1-10, 1997.
Steiner G, Schoenberg MP, Linn JF, Mao L and Sidransky D: Detection of bladder cancer recurrence by microsatellite analysis of urine. Nature Med 3(6):621-624, 1997.
Linn JF, Lango M, Halachmi S, Schoenberg MP and Sidransky D: Microsatellite analysis and telomerase activity in archived tissue and urine samples of bladder cancer patients. Int. J Clin Oncol 19;74(6):625-9, 1997.
30. Jackman SV, Schulam PG and Schoenberg MP: Pseudotumor of the bladder: a late complication of inguinal herniorrhaphy. Urol 50:609-611, 1997.
Halachmi S, Enger C, Rosenthal D, Sidransky D and Schoenberg MP: Molecular diagnosis and staging of bladder cancer. Molecular Urol 1(4):309-314, 1997.
Linn JF, Sesterhenn I, Mostofi FK and Schoenberg MP: The molecular characteristics of bladder cancer in young patients. J Urol 159:1493-1496, 1998.
Baker LA, Chow N-H, Docimo SG, Gearhart JP, Sidransky D and Schoenberg MP: Microsatellite deoxyribonucleic acid analysis to detect bladder cancer in bladder exstrophy. J Urol 160:2192-2193, December, 1998.
Halachmi S, DeMarzo AM, Linn JF, Epstein JI and Schoenberg MP: Extensive squamous cell carcinoma in situ of the urinary bladder masking deeply invasive disease. J Urol 159:203, January, 1998.
Eisenberger CF, Walsh PC, Eisenberger MA, Partin AW, Mostwin JL, Marshall FF and Schoenberg MP: Impact of low grade lymphoma on localized prostate cancer management. Urol 53(1):175-9, January, 1999.
Schoenberg MP, Hortopan S, Schlossberg L and Marshall FF: Anatomical anterior exenteration with urethral and vaginal preservation: Illustrated surgical method. Urol 161:569-572, February, 1999.
Eisenberger CF, Schoenberg MP, Fitter D and Marshall FF: Orthotopic ileocolic neobladder reconstruction following radical cystoprostatectomy: history, technique and the results of the Johns Hopkins Experience, 1986-1998. Urologic Clinics of North America 26(1):149-156, February, 1999.
Docimo SG, Steiner G, Silver RI, Kinsman S, Sidransky D and Schoenberg MP: Molecular surveillance for malignancy after augmentation cystoplasty: feasibility and rationale. Urol 54(3):561, September, 1999.
Eisenberger CF, Schoenberg MP, Enger C, Hortopan S, Shah S, Chow N-H, Marshall FF and Sidransky D: Diagnosis of renal cancer by molecular urinalysis. J Natl Cancer Inst 91(23):2028-32, December, 1999.
Halachmi S, De Marzo A, Chow NH, Halachmi N, Smith AE, Linn JF, Nativ O, Epstein JI, Schoenberg MP and Sidransky D: Genetic alterations in urinary bladder carcinosarcoma: evidence of a common clonal origin. Eur Urol 37(3):350-7, March, 2000.
Han M and Schoenberg MP. The use of molecular diagnostics in bladder Cancer. Urol Oncol 5:87-92, April, 2000.
Han M and Schoenberg MP: In vitro methods for bladder cancer diagnosis and surveillance. Urologic Oncology 5(3):87-92, Apr-May, 2000
Mungan MA, Katja KH, Aben Msc, Schoenberg MP, Visser O, Coebergh, J-W, Witjes, JA and Kiemeney, LALM. Gender differences in stage-adjusted bladder cancer survival. Urology 55(6):876-80, June, 2000.
Feneley MR and Schoenberg MP. Bladder sparing strategies for transitional cell carcinoma. Urology 56:549-60, October, 2000.
Gonzalgo ML, Schoenberg MP and Rodriguez R. Biological pathways to bladder carcinogenesis. Semin Urol Oncol 18:256-63, November, 2000.
Chow NH, Cairns P, Eisenberger CF, Schoenberg MP, Taylor DC, Epstein JI and Sidransky D: Papillary urothelial hyperplasia is a clonal precursor to papillary transitional cell bladder cancer. Int J Cancer 89:514-518, November, 2000.
Han M, Kronz JD and Schoenberg MP. Testicular metastasis of the transitional cell carcinoma of the prostate. J. Urol. 164:2026, December, 2000.
Laufer M, Schoenberg MP and Eisenberger MA. Paclitaxel-induced stomal neuropathy: a unique cause in a patient with ileal conduit. Urology 56:1056, December, 2000.
Wijkstrom H, Cohen SM, Gardiner RA, Kakizoe T, Schoenberg MP, Steineck G and Tobisu K. Prevention and treatment of urothelial premalignant and malignant lesions. Scand J Urol Nephrol Suppl. 2000; (205):116-35.
Han M and Schoenberg MP: Molecular diagnostics for bladder cancer. AUA Update Series, American Urological Association, Inc., Office of Education, Houston, Texas.
Lesson 28, Volume XX, 2001.
Aben K, Macville M, Smeets D, Schoenberg MP, Witjes A and Kiemeney LALM: Absence of karyotype abnormalities in patients with familial urothelial cell carcinoma. Urol. 57:266-269, February 2001.
Parsons JK and Schoenberg MP. Successful conservative management of perforated ileal neobladder. J. Urol. 165:1214-1215, April 2001.
Schoenberg MP. Biomarkers for transitional cell carcinoma (Markers, mom & apple pie). Urol. 57(5):849-851, May, 2001.
Parsons JK, Schoenberg MP and Carter HB. Incidental Renal Tumors: Casting Doubt on the Efficacy of Early Intervention. Urol. 57(6):1013, June, 2001.
Cina SJ, Epstein JI, Endrizzi JM, Harmon WJ, Seay TM and Schoenberg MP. Correlation of cystoscopic impression with histologic diagnosis of biopsy specimens of the bladder. Human Pathology 32(6):630-7, June 2001.
Parsons JK and Schoenberg MP. Case Report: Renal artery pseudoaneurysm occurring after partial nephrectomy. Urol. 58(1):105, July, 2001.
Levi AW, Potter SR, Schoenberg MP and Epstein JI. Clinical significance of denuded urothelium in bladder biopsy. J. Urol. 166:457-460, August 2001.
Cairns P, Esteller M, Herman JG, Schoenberg MP, Jeronimo C, Sanchez-Cespedes M, Chow N-H, Grasso M, Wu L, Westra WB and Sidransky D. Clinical Cancer Research 7(9):2727-30, September 2001.
Sanchez-Cespedes M, Parrella P, Nomoto S, Cohen D, Xiao Y, Esteller M, Jeronimo C, Jordan RCK, Nicol T, Koch WM, Schoenberg MP, Mazzarelli P, Fazio VM and Sidransky D: Identification of a mononucleotide repeat as a major target for mitochondrial DNA mutations in human tumors. Cancer Research 61:7015-7019, 2001.
Schoenberg MP. The William/Buscarini/Stein Article Reviewed. Onc. 15(11):1478.
Sachs MD, Rauen KA, Ramamurthy M, Dodson JL, DeMarzo AM, Putzi MJ, Schoenberg MP and Rodriguez R. Integrin alpha(v) and coxsackie adenovirus receptor expression in clinical bladder cancer. Urology 60(3):531-6, September, 2002.
Aben KK, Witjes JA, Schoenberg MP, Hulsbergen-van de Kaa C, Berbeek AL, Kiemeney LA: Familial aggregation of urothelial cell carcinoma. Int J Cancer 98(2):274-8, March, 2002.
Gongalzo ML, Eisenberger CF, Lee SM, Marshall FF, Hortopan S, Sidransky D and Schoenberg MP: Prognostic significance of preoperative molecular serum analysis in renal cancer. Clinical Cancer Research:1878-1881 (Vol.8), June 2002.
Laufer M, Ramalingam S, Schoenberg MP, Haisfield-Wolfe ME, Zuhowski EG, Trueheart IN, Eisenberger M, Nativ O and Egorin MJ. Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: a phase I and pharmacokinetic study. J. Clin. Oncol., 21(4):697-703, February, 2003.
Tekes A, Kamel IR, Imam K, Chan TY, Schoenberg MP and Bluemke DA: MR imaging features of transitional cell carcinoma of the urinary bladder. AJR Am J Roentgenol. 180(3):771-7, March 2003.
Tekes A, Kamel IR, Chan TY, Schoenberg MP and Bluemke DA. MR imaging features of non-transitional cell carcinoma of the urinary bladder with pathologic correlation. AJR Am J Roentgenol. 180(3):779-84, March 2003.
Gonzalgo ML and Schoenberg MP: Tailoring surveillance of superficial bladder cancer. Contemporary Urology 15(4):16-39, April, 2003.
Hoque MO, Lee C-CR, Cairns P, Schoenberg MP and Sidransky D: Genome-wide genetic characterization of bladder cancer: a comparison of high-density single-nucleotide polymorphism arrays and PCR-based microsatellite analysis. Cancer Research 63:2216-2222, May, 2003.
Parsons JK, Tufaro A, Chang B and Schoenberg MP. Vaginal and pelvic floor reconstruction following exenterative surgery utilizing a rectus abdominis myocutaneous flap. Urology 61(6):1249-52, 2003.
Halachmi S. Shzargel R, Cohjen M. Madeb R, Schoenberg MP, Cohen N and Nativ O. Molecular detection of bladder cancer by fluorescent microsatellite analysis of urine sample and an automated genetic analyzing system. (Submitted)
Book Chapters and Books
Hakimi JM, Rondinelli RH, Schoenberg MP, Barrack ER: Androgen receptors in human prostate cancer: heterogeneous expression, gene mutations and polymorphic variants. Hormones and Cancer 16:449-496, Birkhäuser Boston, January, 1996.
Schoenberg MP: Molecular diagnostics and bladder cancer. Das oberflächliche Harnblasen-karzinom – eine lebenslange panurotheliale Erkrankung? Logos Verlag Berlin 45-51, 1996.
Carter HB, Schoenberg MP: Urologic cancers. Principle and Practice of Medicine. Appleton and Lane.
The Guide to Living with Bladder Cancer. Mark P. Schoenberg, M.D. The Johns Hopkins University Press, Baltimore, MD, 2000.
Schoenberg MP: Chapter 78: Management of Invasive and Metastatic Bladder Cancer. Campbell=s Urology, Eighth Edition. W.B. Saunders, In press.
Linn JF, Halachmi S and Schoenberg MP: Chapter 4: Bladder and other urothelial malignancies. Atlas of Genitourinary Oncology, W.B. Saunders Company, 2002.
Textbook on Urethral Tumors. Chapter 6. Editor: Droller, M. In press.
Carpiniello VL and Schoenberg MP: Management of condyloma acuminata. Medical Outlook for Urologists (audiotape) Vol. 4, No. 3, 1990.
Marshall FF, Brooks JC and Schoenberg MP: Technique of partial nephrectomy. (Videotape) American Urological Association Meeting, San Francisco, CA, May 14-19, 1994. J Urol 151:202A (Abstract #V-9), 1994.