External sites from Expert M.A.O’Donnell, U of Iowa–
Bladder Cancer Research IInstitute
Biologic Therapy in Bladder Carcinoma
BCG+Interferon Alpha for Superficial Bladder Cancer: Physician’s protocol
Projects in Knowledge: New Prospects in the Treatment of Superficial Bladder Cancer.
To learn more about Dr. O’Donnell and the work he is doing for bladder cancer: National Bladder Cancer Research Foundation
Director of Urologic Oncology
Associate Professor, University of Iowa Department of Urology
Dr. O’Donnell is a frequent CME course speaker and a prominent regional and national lecturer.
Urology, Urologic Oncology, BCG and Immunotherapy for Bladder Cancer, Cystectomy, Chemotherapy
Research and Clinical Interests
Development of recombinant BCG for bladder cancer immunotherapy (U.S. patents, 1997, 1999)
Mechanism of anti-cancer action of BCG and cytokines
Role of FAS in mediating cancer apoptosis
Use of phage display peptides for bladder cancer targeting
Dr. O’Donnell has been a member of several medical organizations and presently serves the American Association of Immunologists, the Society for Biological Therapy, and Society of Basic Urologic Research, among others. He is a reviewer for many of the major urologic and cancer research journals and a frequent contributer as well. A board certified urologist, Dr. O’Donnell specializes in the full spectrum of bladder cancer care, from early detection to treatment and bladder reconstruction. He is currently lead investigator on two national clinical trials. His major research interests include the development of recombinant BCG for bladder cancer immunotherapy; mechanism of anti-cancer action of BCG and cytokines; the role of FAS in mediating cancer apoptosis, and the use of phage display derived peptide ligands for cancer targeting. Dr. O’Donnell has received several US patents for his work.
1979— Northwestern University, BA
1984— Duke University School of Medicine, MD
1985-87— Surgery Internship, Brigham and Women’s Hospital
1987-91— Urology Residency, Harvard Program in Urology
1991-93— Fellowship, Beth Israel Hospital and Whitehead Institute of Biomedical Research
1985-91— Fellow, Surgery, Harvard Medical School
1991-97— Instructor, Surgery, Harvard Medical School
1991-93— Associate in Surgery (Urology), Brigham and Women’s Hospital
1991-93— Consultant Urologist, West Roxbury Veteran’s Administration Hospital
1991-97— Assistant Urologist, Harvard University Health Services
1993-96— Associate in Surgery (Urology), Beth Isreal Hospital
1996-00— Associate in Surgery (Urology), Beth Isreal Deaconess Medical Center
1997-00— Consultant Urologist, Harvard University Health Services
1997-00— Assistant Professor, Surgery, Harvard Medical School
2000— Associate Professor, University of Iowa Department of Urology
Affiliations and Offices Held
American Medical Association
American Urological Association
American Association for Cancer Research
American Society for Microbiology
Society for Basic Urologic Research
American College of Surgeons
1993-00— Director, Urologic Laparoscopic Surgery, Beth Israel Hospital
1998-00— Member, Beth Israel Deaconess Cancer Center
1999-00— Director, Beth Israel Deaconess Medical Center Bladder Cancer Center
2000— Member, Holden Comprehensive Cancer Center
Edwin Beer Foundation Research Award
Fulbright/German Academic Exchange Service, Foreign Study Scholar
Alpha Omega Alpha, Duke University
American Foundation for Urologic Disease Scholar
Selected Peer Reviewed Publications
Konety BR, Dhawan V, Allareddy V, O’Donnell MA: Association between volume and charges for most frequently performed ambulatory and nonambulatory surgery for bladder cancer: is more cheaper? J Urol 2004;172:1056-61.
O’Donnell MA, Lilli K, Leopold C; National Bacillus Calmette-Guerin/Interferon Phase 2 Investigator Group: Interim results from a national multicenter phase ii trial of combination bacillus calmette-guerin plus interferon alfa-2b for superficial bladder cancer. J Urol 2004;172:888-93.
Joudi FN, O’Donnell MA: Second-line intravesical therapy versus cystectomy for bacille Calmette-Guerin (BCG) failures. Curr Opin Urol 2004;14:271-5.
Luo Y, Yamada H, Chen X, Ryan AA, Evanoff DP, Triccas JA, O’Donnell MA: Recombinant Mycobacterium bovis bacillus Calmette-Guerin (BCG) expressing mouse IL-18 augments Th1 immunity and macrophage cytotoxicity. Clin Exp Immunol 2004;137:24-34.
Ludwig AT, Moore JM, Luo Y, Chen X, Saltsgaver NA, O’Donnell MA, Griffith TS: Tumor necrosis factor-related apoptosis-inducing ligand: a novel mechanism for Bacillus Calmette-Guerin-induced antitumor activity. Cancer Res 2004;64:3386-90.
Arnold J, de Boer EC, O’Donnell MA, Bohle A, Brandau S: Immunotherapy of experimental bladder cancer with recombinant BCG expressing interferon-gamma. J Immunother 2004;27:116-23.
O’Donnell MA, Luo Y, Hunter SE, Chen X, Hayes LL, Clinton SK: The essential role of interferon-gamma during interleukin-12 therapy for murine transitional cell carcinoma of the bladder. J Urol 2004;171:1336-42.
O’Donnell MA, Luo Y, Hunter SE, Chen X, Hayes LL, Clinton SK: Interleukin-12 immunotherapy of murine transitional cell carcinoma of the bladder: dose dependent tumor eradication and generation of protective immunity. J Urol 2004;171:1330-5.
Nadler R, Luo Y, Zhao W, Ritchey JK, Austin C, Cohen MB, O’Donnell MA, Ratliff TL: Augmentation of Mycobacterium bovis bacillus Calmette-Guerin (BCG)-induced antitumor activity by enhancing delayed type hypersensitivity (DTH). Clin Exp Immunol 2003;131:206-16.
Luo Y, Chen X, O’Donnell MA: Role of Th1 and Th2 cytokines in bacillus Calmette-Guerin (BCG)-induced IFN-gamma production: cytokine promotion and simulation of BCG effect. Cytokine 2003;21:17-26.
Lam JS, Benson MC, O’Donnell MA, Sawczuk A, Gavazzi A, Wechsler M, Sawczuk IS: Bacillus Calmette-Guerin plus interferon alfa 2B intravesical therapy maintains an extended treatment plan for superficial bladder cancer with minimal toxicity. Urol Oncol 2003;21: 354-60.
Weiss GR, O’Donnell M, Loughlin K, Dillman K, Laliberte R, Sherman M: A phase I study of the intravesical administration of recombinant human interleukin-12 in patients with recurrent superficial transitional cell carcinoma of the bladder. J Immunother 2003;26:343-8.
Young S, O’Donnell M, Lockhart E, Buddle B, Slobbe L, Luo Y, DeLisle G, Buchan G: Manipulation of immune responses to Mycobacterium bovis by vaccination with IL-2 and IL-18 secreting recombinant BCG. Immunol Cell Biol 2002;80:209-15.
Young SL, O’Donnell MA, Buchan GS: IL-2-secreting recombinant bacillus Calmette Guerin can overcome a type 2 immune response and corticosteroid-induced immunosuppression to elicit a type 1 immune response. Int Immunol 2002;7:793-800.
He J, Shen D, O’Donnell MA, Chan HR: Induction of MUC1-specific cellular immunity by a recombinant BCG expressing human MUC1 and secreting IL2. Int J Oncol 2002;20:1305-11.
Luo Y, Chen X, Han R, O’Donnell MA: Recombinant bacille Calmette-Guerin (BCG) expressing human interferon-alpha 2B demonstrates enhanced immunogenicity. Clin Exp Immunol 2001;123:264-70.
O’Donnell, MA, Krohn J, DeWolf WC: Salvage intravesical therapy with interferon-alfa 2B plus low dose BCG is effective in patients with superficial bladder cancer previously failing BCG alone. J Urol 2001;166:1300-5.
Maranchie JK, Bouyounes BT, Zhang PL, O’Donnell MA, Summerhayes IC, DeWolf WC: Clinical and pathological characteristics of micropapillary transitional cell carcinoma: a highly aggressive variant. J Urol 2000;163:748-751.
Pavlovich CP, Kraling BM, Stewart RJ, Chen X, Bochner BH, Luster AD, Poppas DP, O’Donnell MA: BCG-induced urinary cytokines inhibit microvascular endothelial cell proliferation. J Urol 2000;163:2014-2021.
Luo Y, Chen X, Szilvasi A, O’Donnell MA: Co-expression of interleukin-2 and green flourescent protein reporter in mycobacteria: in vivo application for monitoring antimycobacterial immunity. Mol Immunol 2000;37:527-36.
Luo Y, Chen X, Downs T, DeWolf WC, O’Donnell MA: Interferon-alfa 2B enhances BCG-induced T helper type one responses in patients undergoing intravesical immunotherapy. J Immunol 1999;162:2399-2405.
Slobbe L, Lockhart E, O’Donnell MA, Mackintosh C, Buchan G: An in vivo comparison of BCG and cytokine secreting BCG vaccines. Immunology 1999;96:517-523.
Luo Y, Chen X, Han R, Chorev M, DeWolf WC, O’Donnell MA: Mutated ras p21 as a target for cancer therapy in mouse transitional cell carcinoma (TCC). J Urol 1999;162;1519-1526.
O’Donnell MA, Luo Y, Chen X, Szilvasi A, Hunter SE, Clinton SK: Role of IL-12 in the induction and potentiation of IFN-gamma in response to Bacillus Calmette-Guérin (BCG). J Immunol 1999;163:4246-4252.
Jackson AM, Ivshina AV, Senko O, Kuznetsova A, Sundan A, O’Donnell MA, Clinton S, Alexandroff AB, Selby PJ, James K, Kuznetsov VA. Prognosis of bacillus Calmette-Guerin therapy of superfical bladder cancer by immunological urinary measurements: Statistically weighted syndromes analysis. J Urol 1998;159:1054-63
Poppas DP, Folkman J, Pavlovich CP, Voest E, Chen X, Luster AD, O’Donnell MA: Intravesical BCG induces the anti-angiogenic chemokine IP-10. Urology 1998;52:268-76.
Chen L, Chen D, Block E, O’Donnell MA, Kufe DW, Clinton SK: Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer. J Immunol 1997;159:351-9.
Downs TM, Szilvasi A, O’Donnell MA: Pharmacological biocompatibility between intravesical prepartions of BCG and inteferon-alfa 2B. J Urol 1997;158:2311-15.
Fujimoto T, O’Donnell MA, Szilvasi A, Yang H, Duda RB: Bacillus Calmette-Guerin plus IL-2 and/or GMCSF enhances immunocompetent cell production of interferon-gamma, which inhibits B16F10 melanoma cell growth in vitro. Cancer Immunol Immunother 1996;42:280-4.
Luo Y, Szilvasi A, Chen X, DeWolf WC, O’Donnell MA: A novel method for monitoring Mycobacterium bovis BCG trafficking using recombinant BCG expressing green fluorescent protein. Clin Diag Lab Immunol 1996;3:761-8.
O’Donnell MA, Aldovini A, Duda RB, Yang H, Young R, DeWolf, WC: Recombinant Mycobacterium bovis BCG secreting functional interleukin-2 enhances gamma interferon production by splenocytes. Infect Immun 1994;62:2508-14.
Yamada H, Luo Y, O’Donnell MA. Differential chemokine expression by bladder cancer as a potential regulator of local immunotherapeutic responses. J Urol 2002;167(4 suppl):115, no. 458.
Yamada H, Luo Y, O’Donnell MA. IFN-gamma up-regulates toll-like receptor 4 functions and cooperates with LPS to produce MDC and IP-10 in human bladder cancer cell line RT4. J Urol 2002;167(4 suppl):7, no. 29.
Luo Y, Chen X, O’Donnell MA. Recombinant BCG expressing IL-18 enhances immune responses to mycobacterium and foreign immunogen. J Urol suppl 2002;167(4 suppl):115, no. 460.
O’Donnell MA, Hartman K, National Phase II BCG/IFN-alpha Investigator Group. An evaluation of BCG plus interferon-alpha-2B toxicity in a national multicenter phase II trial. J Urol 2002;167(4 suppl):188, no. 760.
Lam JS, Benson MC, O’Donnell MA, Sawczuk A, Gavazzi A, Wechsler M, Sawczuk IS. Bacillus Calmette-Guerin plus interferon alfa 2B intravesical therapy maintains an extended treatment plan for superficial bladder cancer with minimal toxicity. J Urol 2002;167(4 suppl):190, no. 765.
O’Donnell MA, Lilli K, Leopold C. Interim results from a national multicenter phase II trial of combination BCG plus interferon-alfa-2B for superficial bladder cancer. J Urol 2003;169(4 suppl):256, no. 993.
O’Donnell MA, Evanoff D, Luo Y. Studies on gemcitabine as an intravesical agent for superficial bladder cancer. J Urol 2003;169(4 suppl):131, no. 508.
Luo Y, Chen X, O’Donnell MA. Use of PSA to measure tumor growth in an orthotopic bladder cancer model. J Urol 2003;169(4 suppl):131, no. 505.
Luo Y, Yamada H, Chen X, O’Donnell MA. Recombinant BCG expressing IL-18 (IL-18 rBCG) enhances macrophage cytotoxicity against mouse bladder cancer cell line MBT-2 in vitro. J Urol2003;169 (4 suppl):128, no. 496.
Selected Book Chapters
O’Donnell MA. Bladder cancer, TCC, superficial (CIS, Ta, T1). In Gomella and Dambro, eds., 5 Minute Urology Consult. Baltimore: Williams & Wilkins, 2000.
O’Donnell MA. Intravesical therapy. In Kursh and Ulchaker, eds., Office Urology. Totowa, NJ: Humana Press, Inc., 2000.
O’Donnell MA. Use of Intravesical BCG in treatment of superficial bladder cancer. In: Droller, ed., Bladder Cancer: Current Diagnosis and Treatment. Totowa NJ: Humana Press Inc., 2001.
O’Donnell MA. Superficial bladder cancer. In Furie, Cassileth, Atkins, Mayer, eds., Clinical Hematology and Oncology: Presentation, Diagnosis, and Treatment. Philadelphia: Churchill Livingston, 2003.
O’Donnell MA, Burns J. Intravesical BCG in treatment and prophylaxis of urothelial bladder cancer. In Droller, ed., Urothelial Cancer: American Cancer Society Atlas of Clinical Oncology. Hamilton Ontario: BC Decker, Inc., 2003.